Spermidine is a polyamine that carries a positive charge that interacts with negatively charged molecules such as RNA, DNA, and proteins. It synchronizes a myriad of biological processes, thus maintaining membrane integrity and controlling volume and intracellular pH. Polyamines play significant roles in cell metabolism, cell growth, proliferation, and survival. The polyamine levels in organisms vary per organism and decline throughout aging.

Spermidine counteracts aging and promotes longevity by inducing autophagy to facilitate the rejuvenation of cell constituents. It is the body?s way of replacing old and damaged cells to regenerate newer and healthier cells.

Autophagy is a regulated cell mechanism that eliminates dysfunctional cell components and allows the regeneration and recycling of cellular components. For this reason, autophagy has an expansive anti-aging potential to the point that most, if not all, behavioral, pharmacological, nutritional, or genetic manipulations that extend longevity require autophagy to be efficient.