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Benefits

How To Use

Evidence

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TUDCA Capsules (Tauroursodeoxycholic acid)

"The Powerful Healing Acid"

Tauroursodeoxycholic acid (TUDCA) is a bile acid that shows very promising benefits for liver and gallbladder health and is also beginning to show benefits for the entire body, including the brain.

Benefits

How To Use

Evidence

benefits

How

TUDCA Capsules (Tauroursodeoxycholic acid)

can help you:

TUDCA Stimulates Bile Flow, Heals Mitochondria In Liver Tissue, Reduces Liver Enzymes, Heals The Liver Bile Duct, Supports Intestinal Health, Supports Metabolism/Thyroid Health.

Metabolism

  • A 1996 study conducted by Crosignani et al. discovered that subjects who took 500, 1000, or 1500mg of TUDCA daily for six months were able to reduce liver enzymes significantly.
  • TUDCA can also act as a chemical chaperone to enhance protein folding and protect cells against endoplasmic reticulum stress (1).
  • TUDCA has a powerful ability to improve bile flow. In fact studies have shown that TUDCA can improve bile flow by as much as 500% (2).
  • TUDCA doesn’t just improve flow but also improves bile quality and also encourages the microbes within your body to create more of your own TUDCA (2).
  • The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure (3).

Brain Health

  • Early studies on mice TUDCA seems to be showing positive results, with studies showing that TUDCA reduced Aβ plaques in the brains of mice with symptoms of Alzheimer’s disease (AD). It also prevented memory deficits in a mouse model of AD. And is now being considered a potential strategy in the prevention and treatment of AD (4).
  • Scientists are still unclear as to how TUDCA protects against Parkinson's disease, but they believe it may be that TUDCA helps rescue the function of the mitochondria and prevent c-Jun N-terminal kinase (JNK) activation. With the JNK pathway being what leads to the death of neurons in Parkinson’s disease (5)
  • Waking Action of Ursodeoxycholic Acid (UDCA) Involves Histamine and GABAA Receptor Block, thefore avoid using before bed (6).
DOSAGE STRATEGY

How to use

TUDCA Capsules (Tauroursodeoxycholic acid)

500mg-1000mg per day (1-2 capsules), with food.

General population:

500mg-1000mg per day (1-2 capsules), with food.

Adults:

500mg-1000mg per day (1-2 capsules), with food.

500mg
mg of

Ideal for:

Best used daily, for 2-3 month cycles.

Liver support, Digestion, Steroid usage.

CAUTIONS

TUDCA Capsules (Tauroursodeoxycholic acid)

safety and
medication interactions.

Safety assessment

Strong safety profile.

Safety studies

Not available.

Medication interactions

  • Do not use in cases of gallbladder dysfunction or diagnosed gallbladder issues.

Side Effects / Contraindications

  • Do not use in cases of gallbladder dysfunction or diagnosed gallbladder issues.

‍

Allergies

  • None known.

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TUDCA Stimulates Bile Flow, Heals Mitochondria In Liver Tissue, Reduces Liver Enzymes, Heals The Liver Bile Duct, Supports Intestinal Health, Supports Metabolism/Thyroid Health.

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TUDCA is one of my personal favourites. I use TUDCA if I have digestive issues or want a boost in metabolism (TUDCA increases thyroid output). TUDCA is also excellent for improving fat digestion.

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Other Resources

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Scientific Citations

1
Chemical chaperone, TUDCA unlike PBA, mitigates protein aggregation efficiently and resists ER and non-ER stress induced HepG2 cell death
2
TUDCA prevents cholestasis and canalicular damage induced by ischemia-reperfusion injury in the rat, modulating PKCalpha-ezrin pathway
3
Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis
4
The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure
5
Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice
6
Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson's Disease