Benefits
Unlike other forms of thiamine supplementation, TTFD’s molecular structure allows it to pass through intestinal and cellular membranes without the requirement for a transport system. Once inside the cell, it can be activated and used as a cofactor in important biochemical processes. TTFD also has a demonstrated capacity to penetrate the blood brain barrier and increase thiamine levels in the brain and central nervous system, where it may be used to support optimal cognition and maintain autonomic nervous system function. Due to its superior bioavailability, TTFD can be taken in much lower doses than what is considered the “therapeutic dose” of other forms such as thiamine salts.
Brain
- The activity of other enzymes are also influenced by thiamine phosphate esters, where thiamine is not acting as a cofactor but is instead involved in: Allosteric regulation of pyridoxal kinase (enzyme involved in vitamin B6 activation) (4),
- Thiamine plays a role in the activity of glutamate dehydrogenase (one enzyme responsible for glutamate clearance to reduce neuroexcitoxicity) (5)
- Allosteric activation of malate dehydrogenase (a mitochondrial enzyme involved in ATP synthesis) (6).
- Although we must be careful of addiction induced by drugs such as , thiamine tetrahydrofurfuryl disulfide (TTFD), a popular thiamine derivative, is a potential agent for the activation of d
Energy
- Insufficient thiamine can downregulate key energy producing enzymes and therefore reduce the rate at which cells are able to synthesize energy. A more recent discovery has shown that thiamine is necessary for the alpha-oxidation of phytanic acid and 2- hydroxy straight-chain fatty acids, through the action of an enzyme called HACL-1 & 2 (1).
- Another thiamine-dependent Krebs cycle enzyme complex is alpha-ketoglutarate dehydrogenase. Located in the mitochondria of the cell, this enzyme is involved in the processing of both glucose and fats for energy, as well as processing amino acids and neurotransmitters (2).
- Dietary proteins are broken down into amino acids, and one class of amino acids is the branched-chain amino acids (valine, leucine, and isoleucine). The thiamine-dependent enzyme, branched-chain-keto acid dehydrogenase, is required to process and make use of these specific amino acids (3).
How to use
THIAMAX - TTFD (Thiamine Tetrahydrofurfuryl Disulfide) Capsules
Start at half a capsule (50mg) and work your way up to your threshold level.
Start at half a capsule (50mg) and work your way up to your threshold level.
Need to find the right dose for you? Consider coaching.
Dosing strategy:
Best used in cyclical fashion.
Ideal for:
Athletes, Students, Fatigue, Focus.
Quality
All vendors are vetted for quality, to ensure they contain the right active ingredients and ratios. Each vendor provides a Certificate of Analysis ℹ️, to ensure accurate dosing, and a product free of contaminants/heavy metals. Further, when brands we work with have been randomly pulled off the shelf and tested by Labdoor, they have tended to score A+ ℹ️.
Efficacy
Before listing products, we compile a list of available research, to determine if claims match the evidence. Likewise, we scour the the internet to gauge people’s experience with each product. Most of the products listed typically score at least [4.5/5 from reviews]. All the studies we’ve found are listed at the bottom of the page, under citations.
Medication interactions and allergies
Please consult your healthcare professional before making any changes to your lifestyle or regime.
For further information on contraindications and allergies, please visit the vendors website.
Buy from a BYB
THIAMAX is a high grade quality, TTFD supplement that makes it easy to use. With the above factors taken into consideration, it is important to choose a form of thiamine which can bypass these potential difficulties. And here is where TTFD comes in.
THIAMAX/TTFD is a powerful vitamin to enhance energy, focus and mood. It provides a clean boost in energy and supports metabolic health. I'm a huge fan.
