August 24, 2020
What is Leaky Gut?
Most people have an idea of how important the health of our good bacteria are, but the health of our “gut barrier” or intestinal mucosa is equally important, this is what determines what is absorbed from our intestinal tract and what is eliminated.
Along the intestinal tract we have many microvilli, which are finger-like projections that increase the area of absorption in our gut, and help to absorb our nutrients, if they get damaged it can lead to the intestinal barrier becoming “leaky” and larger proteins and toxins that should be eliminated, can get absorbed into the bloodstream.
—> This is what is known as leaky gut.
What Causes Leaky Gut?
You Can Maintain A Healthy Gut By:
Larazotide acetate is a first-in-class tight junction (TJ) regulator under development as an adjunct to a GFD. Larazotide acetate appears to prevent opening of intestinal TJs by promoting TJ assembly and actin filament rearrangement, which prevents gluten from reaching the intestinal submucosa and triggering an inflammatory response.
Larazotide acetate is an oral peptide derived from zonula occludens that acts as a tight junction regulator and zonulin antagonist.
It binds to receptors of apical intestinal cells and antagonises zonulin, preventing the opening of the epithelial intestinal tight junctions caused by gluten/gliadin, glyphosate, pro-inflammatory cytokines, zonulin bacterial antigens such as lipopolysaccharide (LPS) and bacterial dysbiosis (2).
Larazotide acetate is being touted as a promising non-dietary treatment for coeliac disease and has passed multiple clinical trials (3).