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Evidence

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NSI-189 (Nootropic Supplement)

"The Novel Neurogenic Antidepressant"

NSI-189 is a novel neurogenic antidepressant. Neurogenic drugs promote the development and growth of new neurons, or brain cells. This means that NSI-189 could potentially repair damaged or missing brain cells that lead to a person being unable to experience happiness – or, in other words, who are depressed.

Benefits

How To Use

Evidence

benefits

How

NSI-189 (Nootropic Supplement)

can help you:

NSI-189 is a neurogenic. It allows the brain to develop healthy brain cells at a quicker rate than usual, which means that people suffering from depression, mental disorders, or degenerative conditions might all benefit from using NSI-189. This compound has also been shown to possess an anti-stress effect.

Brain

  • Possesses antidepressant properties that may improve cognitive function, treat traumatic brain injury, Alzheimer's Disease (AD), Post-Traumatic Stress Disorder (PTSD), and stroke, and prevent cognitive and memory decline in aging (1).
  • NSI-189 can increase neurotrophic factors such as Stem Cell Factor (SCF), Brain-Derived Neurotrophic Factor (BDNF), Vascular Endothelial Growth Factor (VEGF), and Glial-Derived Neurotrophic Factor (GDNF) (2).
  • NSI-189 may effectively treat MDD as well as other psychiatric disorders by increasing neurogenesis (growth) in the hippocampus (3).
  • NSI-189 is a benzylpiperizine-aminiopyridine, a novel chemical entity that stimulates neurogenesis of human hippocampus-derived neural stem cells (4).
  • NSI 189 is currently in research for treating other neurological disorders such as Alzheimer's disease, brain injury, stroke, traumatic stress disorder (5).

Longevity

  • A rise in the energy levels, and increase libido, and sexual performance has been noted by some individuals (6).
  • NSI-189 may be able to protect nerves from toxicity in diabetes. It may help with nerve pain and neuropathy in diabetes (7).
DOSAGE STRATEGY

How to use

NSI-189 (Nootropic Supplement)

40mg-120mg daily.

General population:

40mg-80mg daily.

Adults:

40mg-80mg daily.

Need to find the right dose for you?

Consider getting a custom stack designed.

40mg-80mg daily.
mg of

Ideal for:

2-3 weeks are when the effects are most apparent.

Low mood, students, athletes, fatigue.

CAUTIONS

NSI-189 (Nootropic Supplement)

safety and
medication interactions.

Safety assessment

Antidepressant with novel action appears safe, effective in clinical trial (R).

Safety studies

Not available.

Medication interactions

  • Please consult your healthcare professional before using this compound. It interacts with many medications.

Side Effects / Contraindications

  • Please consult your healthcare professional before using this compound. It interacts with many medications.

Allergies

  • None known.

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NSI-189 is a neurogenic. It allows the brain to develop healthy brain cells at a quicker rate than usual, which means that people suffering from depression, mental disorders, or degenerative conditions might all benefit from using NSI-189. This compound has also been shown to possess an anti-stress effect.

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The experimental antidepressant NSI-189 aims to support the brain through a unique mechanism.

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Scientific Citations

1
The SAGE Encyclopedia of Stem Cell Research
2
The Neurogenic Compound, NSI-189 Phosphate: A Novel Multi-Domain Treatment Capable of Pro-Cognitive and Antidepressant Effects
3
Enhancement of Synaptic Plasticity and Reversal of Impairments in Motor and Cognitive Functions in a Mouse Model of Angelman Syndrome by a Small Neurogenic Molecule, NSI-189
4
The Neurogenic Compound, NSI-189 Phosphate: A Novel Multi-Domain Treatment Capable of Pro-Cognitive and Antidepressant Effects
5
The SAGE Encyclopedia of Stem Cell Research
6
NSI-189 and quick onset effects, especially for libido
7
NSI-189 Nootropics Antidepressant Drug CAS 1270138-40-3 White Powder 99% Purity