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Evidence

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Methylene Blue (Supplement)

"19th Century Discovery, Holding Strong"

Methylene Blue is a synthetic compound used as a nootropic to increase memory, mood and longevity. Research into Methylene Blue for its therapeutic value goes back to the late 1800’s. But it’s only in the last couple of decades that scientists have been able to decode exactly how Methylene Blue works in the brain. All the way down to the molecular level in mitochondria.

Benefits

How To Use

Evidence

benefits

How

Methylene Blue (Supplement)

can help you:

Methylene Blue is currently being studied as potential therapy for mild cognitive impairment, Alzheimer’s and Parkinson’s disease, and other neurodegenerative disorders. All sharing a common problem with mitochondrial function.

Brain

  • Methylene Blue inhibits monoamine oxidase and acetylcholinesterase activity which increases levels of catecholamines and acetylcholine. And boosts serotonin and norepinephrine affecting anxiety, depression and memory (1).
  • Methylene Blue assists brain cell respiration by increasing oxygen. And donating electrons to the electron transport chain within mitochondria. This same process is used to feed mitochondrial ATP when you eat. So MB provides this fuel without you having to eat (2).
  • Neuroprotectant: Methylene Blue is a potent antioxidant. Reactive oxygen species are produced inside mitochondria. The first free radical that is formed inside a cell is superoxide. MB will bind to superoxide and reduce it to water. It stops the oxidative cascade at its very beginning (3).
  • Methylene Blue quickly crosses the blood-brain barrier. It improves mitochondrial efficiency and respiration, acts as an antioxidant, and increases brain cell lifespan. Resulting in improved memory and mood 4).

Longevity

  • Alzheimer’s disease and other forms of dementia are associated with a buildup of the protein Tau. Clinical trials show that Methylene Blue inhibits Tau formation. And is under consideration as a treatment for Alzheimer’s (5).
  • Methylene Blue boosts neuron resistance to the formation of amyloid plaques and neurofibrillary tangles. And helps repair impairments in mitochondrial function and cellular metabolism (6).
  • Research shows that Methylene Blue is an effective anti-aging nootropic. MB increases mitochondrial complex IV by 30%, enhances cellular oxygen consumption by 37-70%, increases heme synthesis, and reverses premature senescence caused by H2O2 or cadmium (7).
DOSAGE STRATEGY

How to use

Methylene Blue (Supplement)

0.5mg-5mg***

General population:

0.5mg-5mg*** Methylene Blue shows a hormetic dose-response, with opposite effects at low and high doses.

Adults:

0.5mg-5mg*** Methylene Blue shows a hormetic dose-response, with opposite effects at low and high doses.

Need to find the right dose for you?

Consider getting a custom stack designed.

N/A
mg of

Ideal for:

Best used every other day. Not consecutively.

Students, Athletes, Studying, Longevity, Health.

CAUTIONS

Methylene Blue (Supplement)

safety and
medication interactions.

Safety assessment

DO NOT COMBINE WITH ANY OTHER COMPOUND THAT INCREASES SEROTONIN.

Safety studies

Not available.

Medication interactions

  • Please consult with your healthcare professional before using this compound.
  • May cause serotonin syndrome, do not combine with other nootropics.

Side Effects / Contraindications

  • Please consult with your healthcare professional before using this compound.
  • May cause serotonin syndrome, do not combine with other nootropics.

‍

Allergies

  • Aanaphylaxis resulting from methylene blue has been very rarely reported in the medical literature. To the extent of our knowledge, there have been only two reports of anaphylaxis after methylene blue dye was used for sentinel lymph node mapping in adults

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Methylene Blue is currently being studied as potential therapy for mild cognitive impairment, Alzheimer’s and Parkinson’s disease, and other neurodegenerative disorders. All sharing a common problem with mitochondrial function.

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Methylene blue enhances my reading speed and comprehension abilities. It seems to help me get into a flow state much easier too. I like how it makes me function at a very low dose (50-100mcg).

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Scientific Citations

1
The Role of Methylene Blue in Serotonin Syndrome: A Systematic Review
2
Methylene Blue Administration Is Associated with Decreased Cerebral Oximetry Values
3
Methylene Blue Is Neuroprotective Against Mild Traumatic Brain Injury
4
Methylene Blue Improves Mitochondrial Respiration and Decreases Oxidative Stress in a Substrate-Dependent Manner in Diabetic Rat Hearts
5
Protective Role of Methylene Blue in Alzheimer's Disease via Mitochondria and Cytochrome C Oxidase
6
Methylene Blue Activates the PMCA Activity and Cross-Interacts With Amyloid β-peptide, Blocking Aβ-mediated PMCA Inhibition
7
Targeting Mitochondrial Dysfunction in CNS Injury Using Methylene Blue; Still a Magic Bullet?