Search our website to find what you need!
Other resources: Supplement Products, Webinars, Podcast and Blog.
J147 is an exciting new compound that is extremely potent, safe in animal studies and orally active. J147 is a potential AD therapeutic due to its ability to provide immediate cognition benefits, and it also has the potential to halt and perhaps reverse disease progression in symptomatic animals as demonstrated in these studies (Prior et al., 2013).
J147 increased transcription factor Egr3 mRNA expression 8-fold following one hour of treatment, while Ngf mRNA was up-regulated 2.8-fold. HT22 cells do not make BDNF. Also up-regulated was mRNA from another member of the Egr family, Egr1, with a 2.5-fold increase and mRNA from a member of the Spred family, Spred2, with a 2.7-fold increase. J147 treatment of aged huAPP/PS1 mice increases the expression levels of several proteins involved in neurotrophin signaling. Members of the neurotrophin family maintain neuronal survival, axonal guidance and cell morphology and are key players in cognition and memory formation.
General population:
Mouse studies used dosages of 10 mg/kg.
Adults:
Mouse studies used dosages of 10 mg/kg.
Need to find the right dose for you?
Consider getting a custom stack designed.
Ideal for:
Best used in cycles.
Memory enhancement, Cognitive decline
Strong safety profile from preliminary studies.
Not available.
J147 increased transcription factor Egr3 mRNA expression 8-fold following one hour of treatment, while Ngf mRNA was up-regulated 2.8-fold. HT22 cells do not make BDNF. Also up-regulated was mRNA from another member of the Egr family, Egr1, with a 2.5-fold increase and mRNA from a member of the Spred family, Spred2, with a 2.7-fold increase. J147 treatment of aged huAPP/PS1 mice increases the expression levels of several proteins involved in neurotrophin signaling. Members of the neurotrophin family maintain neuronal survival, axonal guidance and cell morphology and are key players in cognition and memory formation.
BUY NOW
BUY NOWBUY NOWBUY NOWBUY NOWBUY NOWBUY NOW
I have personally not tried this compound, although, it appears to be promising.
