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Benefits

How To Use

Evidence

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J-147 Nootropic

"Anti-Aging Nootropic Properties"

J147 is an exciting new compound that is extremely potent, safe in animal studies and orally active. J147 is a potential AD therapeutic due to its ability to provide immediate cognition benefits, and it also has the potential to halt and perhaps reverse disease progression in symptomatic animals as demonstrated in these studies (Prior et al., 2013).

Benefits

How To Use

Evidence

benefits

How

J-147 Nootropic

can help you:

J147 increased transcription factor Egr3 mRNA expression 8-fold following one hour of treatment, while Ngf mRNA was up-regulated 2.8-fold. HT22 cells do not make BDNF. Also up-regulated was mRNA from another member of the Egr family, Egr1, with a 2.5-fold increase and mRNA from a member of the Spred family, Spred2, with a 2.7-fold increase. J147 treatment of aged huAPP/PS1 mice increases the expression levels of several proteins involved in neurotrophin signaling. Members of the neurotrophin family maintain neuronal survival, axonal guidance and cell morphology and are key players in cognition and memory formation.

Longevity

  • J-147 enhances mitochondrial function and is very effective in preventing oxidative stress. For example, J147 increases mitochondrial function by improving ATP levels (inhibiting ATP synthase, specifically ATP5A (1).
  • Fruit flies that were given J147 had a longer lifespan (9.5-12.8%) due to the effects on mitochondria. J147 can also reduce aging of the brain from use of γ-glutamyl amino acids and BCAAs (2).
  • In animal models, J147 has shown to decrease blood Glucose and HbA1c levels by increasing AMPK (3).



Nootropic

  • J147 reverses cognitive impairment in a mouse model of Alzheimer’s Disease (AD), and can improve Amyloid-Beta (Aβ) metabolism and reduce levels in the brain by reducing protein levels of β-Secretase (BACE) (4). 
  • In animal models of AD, J147 can protect BBB permeability homeostasis and improve vascular function in the brain (5).
  • J147 grows the brain by increasing levels of both Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) (6).


DOSAGE STRATEGY

How to use

J-147 Nootropic

Dosage yet to be determined. Please consult your healthcare professional.

General population:

Mouse studies used dosages of 10 mg/kg.

Adults:

Mouse studies used dosages of 10 mg/kg.

Mouse studies used dosages of 10 mg/kg.
mg of

Ideal for:

Best used in cycles.

Memory enhancement, Cognitive decline

CAUTIONS

J-147 Nootropic

safety and
medication interactions.

Safety assessment

Strong safety profile from preliminary studies.

Safety studies

Not available.

Medication interactions

  • Please consult with your healthcare professional before using this compound.

Side Effects / Contraindications

  • Please consult with your healthcare professional before using this compound.

Allergies

  • Please consult with your healthcare professional before using this compound.

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J147 increased transcription factor Egr3 mRNA expression 8-fold following one hour of treatment, while Ngf mRNA was up-regulated 2.8-fold. HT22 cells do not make BDNF. Also up-regulated was mRNA from another member of the Egr family, Egr1, with a 2.5-fold increase and mRNA from a member of the Spred family, Spred2, with a 2.7-fold increase. J147 treatment of aged huAPP/PS1 mice increases the expression levels of several proteins involved in neurotrophin signaling. Members of the neurotrophin family maintain neuronal survival, axonal guidance and cell morphology and are key players in cognition and memory formation.

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I have personally not tried this compound, although, it appears to be promising.

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Scientific Citations

1
The mitochondrial ATP synthase is a shared drug target for aging and dementia
2
A comprehensive multiomics approach toward understanding the relationship between aging and dementia
3
A novel curcumin derivative for the treatment of diabetic neuropathy
4
The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice
5
A comprehensive multiomics approach toward understanding the relationship between aging and dementia
6
The Neurotrophic Compound J147 Reverses Cognitive Impairment in Aged Alzheimer's Disease Mice
7
A comprehensive multiomics approach toward understanding the relationship between aging and dementia