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Benefits

How To Use

Evidence

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Bitter Melon Extract

"The Modern Day, Essential"

Bitter melon has been found to activate the cellular machinery to regulate energy production (AMPK) and the way that fats are handled by the liver. Activation of this metabolic pathway is important to aging. It is sometimes referred to as “exercise in a bottle” because activation of AMPK is an aspect of the benefits derived from exercise. This herb is beneficial for virtually anyone who is serious about their body composition and blood sugar balance.

Benefits

How To Use

Evidence

benefits

How

Bitter Melon Extract

can help you:

Bitter melon helps normalize blood sugar levels, fights bacterial infections & viruses, improves digestive & liver health, reduces respiratory symptoms and may help prevent obesity & heart disease.

Longevity

  • Bitter melon increases UCP1 expression in the white adipose tissue (WAT), thereby supports energy homeostasis and balance (9).
  • Bitter melon increases expression of genes related to mitochondria biogenesis, thereby supporting, greater energy efficiency and function (10).
  • In Asia, Africa, and the Caribbean for its edible fruit. It is traditionally used in alternative system of medicines as one of the remedy for its anti-diabetic, laxative, anti-ulcer, anti-helminthic and anti-malarial activities (11).

Blood Sugar

  • Bitter melon holds hypoglycemic perspectives owing to different modes of actions, i.e. repairing damaged β-cells, increased insulin levels & its sensitivity, inhibiting the absorption of glucose by inhibiting glucosidase, and also suppresses the activity of disaccharides (5).
  • Bitter melon has a modest hypoglycemic effect and significantly reduces fructosamine levels from baseline among patients with type 2 diabetes. However, the hypoglycemic effect of bitter melon was less than metformin 1,000 mg/day, although this is still very promising (6).
  • Bitter melon is one of the most commonly used vegetable that contains polypeptide-p and is used to control diabetes naturally. Polypeptide-p or p-insulin is an insulin-like hypoglycemic protein, shown to lower blood glucose levels (7).
  • Bitter melon supplementation appears to have benefits in lowering elevated fasting plasma glucose in prediabetes, thereby improving blood sugar control (8).

Body Composition

  • Bitter melon demonstrates a beneficial role in obesity and related complications in metabolic syndrome, via modulating fat and sugar metabolism (1).
  • Bitter melon can modulate fat metabolizing kinases such as AMPKs, genes, and nuclear factors like PPARs, LXRs, and PGC-1α, in liver and skeletal muscle and affected adipocyte differentiation, suggesting an antidiabetic effect (2).
  • In rats body weight and the high level of fasting blood glucose has been improved by the administration of BM extracts about (3).
  • Bitter melon contains PPARα and PPARγ activators, that facilitate lipid metabolism, reduce blood lipids, and cause anti-inflammatory activity. This subsequently reduces fat accumulation, resulting in weight-loss effect (4).
DOSAGE STRATEGY

How to use

Bitter Melon Extract

Take 1 capsule, with a high calorie meal.

General population:

Take 1 capsule, with a high calorie meal.

Adults:

Take 1 capsule, with a high calorie meal.

mg of

Ideal for:

Bitter melon works best when used long term, as it can take time to modulate various enzymes and hormones responsible for excellent health.

Athletes, Blood sugar control, anyone with a family history of diabetes.

CAUTIONS

Bitter Melon Extract

safety and
medication interactions.

Safety assessment

Considered extremely safe for human consumption.

Safety studies

.
Effects of Karela (Bitter Melon; Momordica charantia) on genes of lipids and carbohydrates metabolism in experimental hypercholesterolemia: biochemical, molecular and histopathological study

Medication interactions

  • Caution is advised for those who are on hypoglycaemic medication. Please consult with your healthcare professional.

Side Effects / Contraindications

  • Low blood sugar (Hypoglycaemia)

Allergies

None known.

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Bitter melon helps normalize blood sugar levels, fights bacterial infections & viruses, improves digestive & liver health, reduces respiratory symptoms and may help prevent obesity & heart disease.

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Bitter melon allows me to eat a high carbohydrate diet, without seeing dramatic changes in my blood sugar and insulin levels. In addition, it gives me greater energy levels in the gym and wicked blood sugar

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Scientific Citations

1
Beneficial Role of Bitter Melon Supplementation in Obesity and Related Complications in Metabolic Syndrome
2
Beneficial role of Bitter melon supplementation on obesity and related complications in metabolic syndrome
3
Bitter melon (Momordica charantia): a natural healthy vegetable
4
Effect of wild bitter gourd treatment on inflammatory responses in BALB/c mice with sepsis
5
Bitter melon (Momordica charantia): a natural healthy vegetable
6
Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients.
7
Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency
8
Bitter gourd reduces elevated fasting plasma glucose levels in an intervention study among prediabetics in Tanzania
9
Effect of wild bitter gourd treatment on inflammatory responses in BALB/c mice with sepsis
10
Effect of wild bitter gourd treatment on inflammatory responses in BALB/c mice with sepsis
11
Bitter melon: a panacea for inflammation and cancer