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Evidence

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NACET Powder Supplement (N-Acetyl-L-Cysteine Ethyl Ester)

"Like NAC, But Better."

Recent large clinical trials failed to confirm the supposed beneficial effects of N-acetylcysteine (NAC) in preventing oxidative stress-related diseases. This may be due to its low bioavailability. We thought that esterification of the carboxyl group of NAC to produce N-acetylcysteine ethyl ester (NACET) would drastically increase the lipophilicity of NAC, thus greatly improving its pharmacokinetics. In the present work, we report on representative chemical, pharmacological and anti-oxidant properties of NACET, especially in direct comparison with its congener NAC. We found that NACET is rapidly absorbed in rats after oral administration but reaches very low concentrations in plasma. This is due to a unique feature of NACET: it rapidly enters the cells where it is trapped being transformed into NAC and cysteine. After oral treatment, NACET (but not NAC) was able to increase significantly the glutathione content of most tissues examined, brain included, and to protect from paracetamol intoxication in the rat.

Benefits

How To Use

Evidence

benefits

How

NACET Powder Supplement (N-Acetyl-L-Cysteine Ethyl Ester)

can help you:

The esterification of the carboxyl group to produce N-acetylcysteine ethyl ester increases the lipophilicity of NAC and greatly improves its pharmacokinetics. NACET has much higher bioavailability (around 60%) than NAC. NACET rapidly enters the cells, then is trapped, and transforms into NAC and Cysteine. NACET is found in the cells of different tissues, including brain as it is able to cross the blood-brain barrier. NACET also provides a variety of protective antioxidant effects. NACET may be taken orally and helps increase glutathione. It can accumulate in human erythrocytes. NACET may also behave as a potent protector against hydroperoxide-induced oxidative damage. NACA has superior bioavailability than NAC as well as a molecule to improve the endurance and resident time of bioscaffolds and biomaterials. More than 800 reviews on NAC have been published.

Brain

  • N-Acetyl-L-cysteine ethyl ester powder 59587-09-6, is natural or synthetic substances that can enhance brain function, to improve mental performance. Usually known as Nootropics and smart drugs, they have gained popularity in today’s highly competitive society and are most often used to boost memory, focus, creativity, intelligence and motivation (3).
  • NACET increases circulating hydrogen sulfide (H(2)S), thus representing a good candidate for the oral use as an H(2)S producer, with clear advantages over NAC (4).
  • After oral treatment, NACET (but not NAC) was able to increase significantly the GSH content of most tissues in the rat (including brain), and protected them from paracetamol intoxication (5).

Immune Health

  • A large body of primary research demonstrates that dietary supplementation with the potent antioxidant N-acetylcysteine (NAC) can inhibit RNA virus replication and reduce the severity of associated diseases (1).
  • This modification of NAC permits unprecedented protection of your blood cells from oxidative damage, thus enabling your body’s immune system to effectively defend your body from the ravages of COVID-19 (This is not medical advice). NAC itself has low oral bioavailability because it is rapidly metabolized in your liver before it can reach your tissues, especially the lung epithelium which is most at risk for COVID-19 induced oxidative damage (2).
DOSAGE STRATEGY

How to use

NACET Powder Supplement (N-Acetyl-L-Cysteine Ethyl Ester)

Best combined with Glycine.

General population:

50mg-100mg

Adults:

50mg-100mg

N/A
mg of

Ideal for:

Up to one week for full effects to manifest. Best combined with Glycine.

Brain Health, Neural restoration, students, athletes.

CAUTIONS

NACET Powder Supplement (N-Acetyl-L-Cysteine Ethyl Ester)

safety and
medication interactions.

Safety assessment

Based on NAC strong safety profile, this compound is likely also safe, however, literature reviews are pending.

Safety studies

Not available.

Medication interactions

  • Consult your doctor before administering this supplement.

Side Effects / Contraindications

  • Consult your doctor before administering this supplement.

‍

Allergies

  • Consult your doctor before administering this supplement.

‍

Buy from an Ergogenic trusted vendor

The esterification of the carboxyl group to produce N-acetylcysteine ethyl ester increases the lipophilicity of NAC and greatly improves its pharmacokinetics. NACET has much higher bioavailability (around 60%) than NAC. NACET rapidly enters the cells, then is trapped, and transforms into NAC and Cysteine. NACET is found in the cells of different tissues, including brain as it is able to cross the blood-brain barrier. NACET also provides a variety of protective antioxidant effects. NACET may be taken orally and helps increase glutathione. It can accumulate in human erythrocytes. NACET may also behave as a potent protector against hydroperoxide-induced oxidative damage. NACA has superior bioavailability than NAC as well as a molecule to improve the endurance and resident time of bioscaffolds and biomaterials. More than 800 reviews on NAC have been published.

BUY NOWBUY NOW

NACET has far superior effects over regular NAC, with a lower dosage needed. It is going to be hot in the next couple of years.

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Scientific Citations

1
N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus.
2
N-acetylcysteine: A rapid review of the evidence for effectiveness in treating COVID-19
3
N-Acetyl-L-cysteine ethyl ester (59587-09-6)
4
N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential.
5
N‐acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities