October 9, 2019
☀️VITAMIN D RECEPTOR BOOSTER:
Resveratrol has been shown to: (1) potentiate 1,25D binding to VDR; (2) activate RXR; and/or (3) stimulate SIRT1, an enzyme known to deacetylate nuclear receptors (Dampf et al., 2015). This can be useful for those struggling with low Vitamin D.
⚡️FIGHTS TMAO PRODUCTION:
TMAO predicts the future development of heart disease and adverse events even in humans (Abbasi et al., 2019). Resveratrol has shows potential in rodent models to counteract a rise in TMAO production...Enjoy your red meat in peace (Chen et al., 2016).
Sucrose preference, rearing and nest seeking in animal models are indicative of anhedonia, aka - the inability to experience pleasure. Resveratrol counteracts anhedonia-like behaviours in EVERY animal model of depression (Hurley et al., 2014).
✅PROTECTS LEAKY BLOOD BRAIN BARRIER:
Resveratrol defends blood-brain barrier integrity in mice (Wang et al., 2016).
⬆️UP-REGULATES AMPA SIGNALLING IN THE BRAIN:
AMPA receptors (AMPAR) are ligand-gated glutamatergic ion channels that play a role in excitatory neurotransmission in the brain as well as long term term potentiation (Shepherd et al., 2007).
🛡UP-REGULATES SEROTONIN (5-HT3A) RECEPTOR:
Alcohol is a known antagonist at this same receptor, and the opposite seems to happen during withdrawal. Resveratrol causes up-regulation of this receptor which is an EXCITATORY serotonin receptor and plays a role in reward function (Lee et al., 2011).
Resveratrol possess a plethora of unique benefits. In fact, there’s another flavonoid on my radar, that also posses some rather impressive research. Stay tuned for that one!
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