High Serotonin Slows Metabolism.

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Lucas Aoun

Founder @ BYB

August 14, 2019

Does serotonin cause fat gain? Serotonin is the hibernation chemical. In hibernating animals, the stress of a declining food supply causes increased serotonin production. In humans and animals that don’t hibernate, the stress of winter causes very similar changes. Serotonin lowers temperature by decreasing the metabolic rate. In the winter, more thyroid is needed to maintain a normal rate of metabolism (Ray Peat, 2019). ⁣

Key Facts

😮STRESS INCREASES SEROTONIN OUTPUT IN RAPHE NUCLEI:⁣⁣
Stress triggers adaptive and maladaptive changes in the central nervous system.  It has been shown that cortisol/stress can increase tryptophan hydroxylase mRNA, leading to greater serotonin output from L-Tryptophan (Chamas et al., 2004). ⁣⁣
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👁HIGH SEROTONIN IMPAIRS GLUCOSE CONTROL:⁣⁣
The serotonin transporter (SERT) function is to "recycle" or remove (more accurately) serotonin from the synapse; effectively rendering it inactive. Ie. More SERT = Less serotonin flooding your brain. ⁣⁣
Reduced (SERT) function causes insulin resistance and liver dysfunction independent of food intake (Chen et al., 2012).⁣⁣
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📚SEROTONIN LOWERS MOTIVATION:⁣⁣

Serotonin reduces incentive motivation (Browne & Fletcher, 2016). In other words, increasing Serotonin lowers one’s desire to chase money/reward/goal. In addition, high serotonin can cause EMOTIONAL blunting and apathy, anhedonia - ie. the INABILITY to experience pleasure. ⁣⁣
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(This is not medical advice)⁣⁣
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💥TAKEAWAY:⁣⁣
Serotonin, although important for many biological functions, can cause unwanted fat gain/difficulty losing weight when in EXCESS. Generally, Dopamine, on the other hand encourages MOTIVATION, fat loss, and drive. Stay tuned more info on this soon! ⁣⁣
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