September 4, 2020
What is 5-AMINO-1MQ
This compound is a small, selective membrane permeable molecule that blocks the NNMT enzyme. As fat cells grow larger, they begin to overproduce an enzyme called NNMT.
NNMT = Nicotinamide N-methyltransferase.
This enzyme acts to slow down fat cell metabolism (fat burning).
The administration of this substance to obese mice resulted in a 10-day weight loss of 7% and a 30% reduction in adipose tissue compared to the untreated group, without any reduction in food consumption.
Finally, the blood cholesterol level of the treated animals was equal to that of non-obese animals.
These good results encourage the search for NNMT inhibitors that can be used in human medicine to fight overweight and obesity.
Researchers at the University of Texas discovered a molecule that blocks this metabolic slowdown in white fat cells caused by excess NNMT. By blocking this metabolic slowdown, they were able to increase the metabolism within the white fat cells.
Researchers add that by inhibiting the NNMT enzyme, we can increase fat cell metabolism and reduce the size of white fat deposits. What made it even more effective is that it did not affect the activity of any other enzymes in the metabolic cycles which reduced the risks of any potential side-effects.
DISEASES LINKED TO NNMT
NNMT has been implicated in a number of other diseases including osteoarthritis, metabolic disorders, cardiovascular disease, cancer, Parkinson's disease, kidney disease, and other neurovascular/neurological dysfunctions. 5-amino 1MQ or another variation could be promising to treat a variety of other diseases.
KEY BENEFITS OF 5-AMINO-1MQ